HHP MISSION Stream 1 Funding Call Singapore

Deadline: 26-Oct-2026

The HHP MISSION Stream 1 Funding Call provides grants of up to S$5 million for public research institutions in Singapore investigating immune homeostasis, immune dysregulation, and inflammation as drivers of disease. Projects may run for up to three years, and institutional applications must be submitted by 12:00 p.m. Singapore Standard Time on 26 October 2026.

About the HHP MISSION Stream 1 Funding Call

The Human Health and Potential MISSION Stream 1 Funding Call is an inaugural research initiative of the Government of Singapore. It supports high-quality research that improves understanding of immune-system balance and investigates how immune dysfunction and inflammation contribute to disease. The program seeks to catalyse impactful scientific discoveries while strengthening collaboration and research excellence across Singapore’s public research ecosystem. Purpose of the Funding

The funding call aims to:

- Advance understanding of immune homeostasis - Investigate immune dysregulation - Examine inflammation as a driver of disease - Identify underlying biological mechanisms - Support innovative scientific approaches - Translate research findings into potential interventions - Strengthen collaboration among public research institutions - Develop research excellence within Singapore - Generate knowledge with potential clinical or therapeutic value - Improve understanding and treatment of immune-related conditions Thematic Focus Proposals must address the central theme of: - Immune homeostasis - Immune dysregulation - Inflammation as a driver of disease Projects should establish a clear scientific connection between immune-system processes and disease development, progression, diagnosis, prevention, or treatment. What Is Immune Homeostasis? Immune homeostasis is the process through which the immune system maintains an appropriate balance.

A healthy immune system must:

- Respond effectively to infections - Recognize harmful biological threats - Avoid attacking healthy tissues - Control excessive inflammation - Return to a stable state after an immune response - Interact appropriately with other biological systems When this balance is disrupted, immune dysfunction and chronic inflammation may contribute to disease. What Is Immune Dysregulation? Immune dysregulation occurs when the immune system responds in an abnormal, excessive, insufficient, or misdirected manner.

It may contribute to:

- Autoimmune diseases - Chronic inflammatory conditions - Allergic disorders - Infectious disease complications - Cancer - Metabolic disorders - Neurological conditions - Organ damage - Other immune-related illnesses Research may explore the cellular, molecular, genetic, environmental, or systemic factors contributing to dysregulation. Inflammation as a Driver of Disease Inflammation is a protective response to injury or infection, but persistent or poorly controlled inflammation can contribute to disease.

Projects may investigate:

- Initiation of inflammatory responses - Resolution of inflammation - Chronic inflammation - Tissue-specific immune responses - Immune-cell interactions - Inflammatory signaling pathways - Relationships between inflammation and disease progression - Biomarkers of inflammatory disease - Targets for therapeutic intervention - Prevention of inflammation-related damage Potential Research Approaches

Projects may involve:

- Fundamental biological research - Cellular and molecular studies - Immunological research - Genomics and other omics approaches - Disease-model development - Biomarker discovery - Systems biology - Computational research - Translational research - Preclinical research - Therapeutic-target identification - Intervention development - Research involving clinical samples or health data The proposed approach should be scientifically rigorous and directly connected to the funding theme. Potential Research Topics Subject to the official guidelines, proposals may investigate: - Mechanisms maintaining immune balance - Causes of immune-system dysfunction - Chronic inflammatory pathways - Autoimmunity - Immune tolerance - Host-pathogen interactions - Immune-metabolic interactions - Inflammation and cancer - Inflammation and neurological disease - Tissue-specific immunity - Age-related immune changes - Genetic factors influencing immune responses - Environmental influences on immunity - Biomarkers of immune dysregulation - New therapeutic or preventive approaches These examples are illustrative. Applicants should follow the scope defined in the official call documentation. Funding Amount

Successful projects may receive:

- Up to S$5 million per proposal

The stated maximum includes:

Applicants should ensure that the total request, including the permitted indirect-cost component, does not exceed S$5 million. Understanding the Indirect-Cost Provision Indirect costs support institutional expenses that cannot always be assigned exclusively to one research activity. These may include eligible institutional costs associated with: - Research administration - Facility operations - Shared infrastructure - Financial management - Compliance - Other approved overhead functions The official financial guidelines should be used to calculate the 30% indirect-cost component. Applicants should not assume that the entire S$5 million is available for direct research activities. Funding Duration

Projects may receive funding for:

The work plan should include:

- Annual objectives - Research activities - Milestones - Deliverables - Budget requirements - Risk-management measures - Monitoring indicators - Expected outputs - Translation or follow-up plans Applicants may propose a shorter duration where scientifically appropriate. Who Is Eligible?

Eligibility is limited to

- Public research institutions in Singapore Applications must be coordinated, reviewed, and submitted by the eligible Host Institution. Individual researchers cannot submit applications directly to the HHP MISSION Pro