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Accepting bidsgrantUnited States

Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)

Issued by National Institutes of Health · via Grants.gov — US federal funding opportunities

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Published
3 Nov 2026
Closes
10 Oct 2028, 23:59 UTC
Value
USD 6,000,000
Reference
RFA-NS-28-012
Location
United States
Sector
Healthcare & Pharma

At a glance

National Institutes of Health in United States has published a funding call in healthcare & pharma: “Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)”. Submissions close on 10 October 2028, 701 days from today. The stated value is USD 6,000,000. Quote reference RFA-NS-28-012 in any correspondence with the buyer. FreeTender has recorded 458 notices from this buyer since 2023, 378 of them currently open. There are 390 open healthcare & pharma notices in United States on FreeTender. Bids are submitted to the buyer through Grants.gov — US federal funding opportunities, not through FreeTender.

Key requirements

Taken from the notice by FreeTender. The tender document on the official portal is binding — check it, and any corrigendum, before you bid.

To bid on Grants.gov (US federal)

Applicants need a UEI from SAM.gov and a Grants.gov account registered to their organisation; allow several weeks for registration.

Details

This Notice of Funding Opportunity (NOFO) supports the translation of genome editing and other biologic therapies for Alzheimer's Disease-Related Dementias (ADRD). The program spans the full translational pipeline, from therapeutic lead optimization and drug product development through IND-enabling studies and early clinical evaluation. Supported activities may include optimization of editing constructs and delivery systems; assessment of bioactivity, target engagement, durability, pharmacokinetics, and bioavailability; demonstration of in vivo efficacy; execution of safety pharmacology and toxicology studies; and development of scalable manufacturing processes, formulation strategies, and quality attributes aligned with regulatory expectations.ADRD include Frontotemporal Dementia (FTD); Lewy Body Dementias (LBD), including Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD); Vascular Contributions to Cognitive Impairment and Dementia (VCID); and Multiple Etiology Dementias (MED). Eligibility: Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Estimated total programme funding: USD 6000000

Expected number of awards: 3

CFDA number(s): 93.866

Federal funding opportunity published on Grants.gov. Applications are submitted through Grants.gov — see the official listing.

Context for bidders

We hold 458 notices from National Institutes of Health, going back to May 2023 — 378 of them still open. They buy mostly in Healthcare & Pharma, Education & Training and Water & Environment. There are 390 open Healthcare & Pharma tenders in United States. This one closes in 701 days.

Before you bid on this tender

A quick checklist to help you decide whether to bid and prepare a compliant submission for this healthcare & pharma opportunity. Always verify the details on the official source.

  • Confirm the exact closing date and time (and time zone) on the official portal — deadlines are strict and can be revised by a corrigendum.
  • Read the full notice and every attached document, including the scope, specifications and any bill of quantities or terms of reference.
  • Check the eligibility criteria — prior similar experience, annual turnover, certifications and registrations — and make sure you qualify before investing effort.
  • Prepare any earnest-money deposit (EMD) or bid security and the required formats early; missing or wrongly-formatted documents are a common cause of rejection.
  • Note how bids must be submitted (online or physical), in what format, and whether a digital signature or portal registration is required.
  • Watch for corrigenda and clarifications right up to the deadline — requirements and dates can change.
Common bidding mistakes to avoid →Writing a winning proposal

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